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I am not sure what API medicine is, but my experience with all available of medicine was very mixed and not reliable.
However, the best treatment for internal worms is to raise slowly (in 2-3 days)...

My setup is similar to yours... my display tank is around 800+ liters. The full tank volume might be around 900-1000L with the sump...My adult discus keep breeding in the display tank which I am not...

Frequent water changes are also not for me.... I am currently breeding a Blue Diamond pair. I have put a few plants to keep nitrite low. Last time I changed water around 5% a month ago, which will be...